After seventeen years in prison, the former respected Parisian banker Paul Lavond flees with his friend, the lunatic scientist Marcel that is researching with his wife Malita the miniaturization of animals and human beings to improve the resources of mankind. Paul Lavond was framed for robbery by his scoundrel associates Emil Coulvet, Charles Matin and Victor Radin that had stolen his business while his family was doomed to shame, poverty and tragedy. When Marcel reduces the retarded servant Lachna, he learns that the woman is motionless and only responds to the control of his brain and has a heart attack. After the death of Marcel, Paul Lavond sees the chance to use the miniaturization process as instrument of vengeance and he travels to Paris with the insane Malita disguised of Madame Mandilip, a nice old lady and owner of a dolls store. Paul Lavond, using the identity of Madame Mandilip, befriends his resented and estranged daughter Lorraine Lavond and plots a scheme to revenge and vindicate his family name.
2015年，朋友派出的恶魔推销员遍布世界各大主要城市，致命的病毒就此蔓延，全球愈20亿人丧命。在此之后，朋友开发出的疫苗拯救无数绝望的生灵，他再次被人类奉为神明，朋友帝国的统治进一步加强。 与此同时，以义常（香川照之 饰）为首的“贤知一派”和神奈率领的“冰之女王军”与朋友及其地球防卫军接连展开对抗。在被高墙封闭起来的东京，朋友做出新的预言，“2017年8月20日这天，外星人将来到地球散播更为致命的病毒，全人类都会因此灭亡”。人类危在旦夕，革命军加紧部署，阿区（丰川悦司 饰）、贤知（唐泽寿明 饰）、青蛙仔（宮迫博之 饰）、丸夫（石塚英彦 饰）也相继回到这里。关系人类命运的最终决战即将展开…… 本片根据浦泽直树同名漫画改编，影片简介中涉及的人名均以原著漫画中文版翻译为准。
21世纪中叶，地球环境遭到巨大的破坏，人类文明和信仰不可遏止地崩塌。在一片乱象的关头，名为ROC的科技公司凭借他们研发的“朝圣者7000”智能机器人迅速崛起。朝圣者深入民间每一个角落，帮助人们从生到死处理身边的一切事务。在两条根本原则的约束下，机器人们任劳任怨，不辞辛苦，与此同时也遭遇种种残酷无情的对待。贾克·波根（安东尼奥·班德拉斯AntonioBanderas饰）是ROC旗下的一名保险理赔员，在工作中他意外发现，许多朝圣者不仅被人私自篡改，连根本原则都遭到破坏。
